汪小我 副教授

清华大学自动化系
信息处理研究所 副所长
清华信息科学与技术国家实验室(筹)生物信息学部
清华大学合成与系统生物中心
生物信息学教育部重点实验室

通讯地址:北京清华大学FIT 1-112室 邮编:100084
电话:010-62794294 转808
Email: xwwang@tsinghua.edu.cn   

教育背景

1999年8月–2003年7月 清华大学,自动化系,自动化专业,学士

2007年9月–2008年3月 美国冷泉港实验室,访问学生

2003年9月–2008年7月 清华大学,自动化系,控制科学与工程,博士   


工作履历

2008年7月–2011年11月 清华大学,自动化系,讲师
2011年12月–2015年12月 清华大学,自动化系,副教授
2012年3月–2013年3月 美国加州大学伯克利分校,唐氏杰出学者
2016年1月–现在 清华大学,自动化系,长聘副教授(Tenure,PI,博士生导师)

学术兼职

中国人工智能学会生物信息学与人工生命专业委员会秘书长

中国生物工程学会计算生物学与生物信息学专业委员会委员

国家自然科学基金、香港GRC项目函评人

担任Nature Biotechnology, PNAS, Genome Biolgy, Bioinformatics、PLoS Computational Biology,《科学通报》、《中国科学》等国内外期刊和会议的审稿人   

研究领域

1.生物信息学研究

2.生物组学大数据的信息挖掘

3.模式识别与机器学习方法及应用

4.合成生物系统的设计与控制

奖励与荣誉

国家自然科学基金优秀青年基金,2013

教育部新世纪优秀人才,2013

全国优秀博士学位论文,2010

中国自动化学会科学技术进步奖二等奖(排名第二),2013

国家教学成果二等奖(排名第五),2009

北京市教学成果一等奖(排名第五),2008

学术成果

1.Chao He?, Guipeng Li?, Diekidel M. Nadhir, Yang Chen* , Xiaowo Wang,*  and Michael Q. Zhang*, Advances in computational ChIA-PET data analysis, Quantitative Biology 2016, 4(3): 217–225

2.魏磊,袁野,汪小我*,合成基因线路规模化设计面临的挑战,中国生物工程学报,2017,33(3):372-385

3.Zhe Cao#, Chang Liu#, Jianwei Xu#, Lei You, Chunyou Wang, Wenhui Lou, Bei Sun, Yi Miao, Xubao Liu, Xiaowo Wang*, Taiping Zhang*, Yupei Zhao*, Plasma microRNA panels to diagnose pancreatic cancer: Results from a multicenter study, Oncotarget, 2016, 7(27):41575-41583

4.Ye Yuan, Xinying Ren, Zhen Xie, Xiaowo Wang*, A quantitative understanding of microRNA-mediated competing endogenous RNA regulation, Quantitative Biology 4 (1), 47-57

5.Chao He, Michael Q. Zhang*, Xiaowo Wang*, MICC: an R package for identifying chromatin interactions from ChIA-PET data, Bioinformatics, 2015, 31(23): 3832-4

6.Honglei Liu, Zheng Wei, Antonia Dominguez, Yanda Li, Xiaowo Wang*, Lei S. Qi*, CRISPR-ERA: a comprehensive design tool for CRISPR-mediated gene editing, repression and activation, Bioinformatics, 2015, 31(22):3676-8

7.梁亚茹#, 刘畅#, 王卓然, 董琼叶, 汪小我*, 王钊*. 抗衰老药物对线虫生存曲线影响的荟萃分析. 中国科学 生命科学, 2015, 45(5): 479-487

8.Ye Yuan, Bing Liu, Peng Xie, Michael Q. Zhang, Yanda Li, Zhen Xie*, Xiaowo Wang*, Model-guided quantitative analysis of microRNA-mediated regulation on competing endogenous RNAs using a synthetic gene circuit, Proc Natl Acad Sci U S A, 2015, 112(10):3158-63

9.Honglei Liu, Yanda Li, Xiaowo Wang*, OP-Synthetic: identification of optimal genetic manipulations for the overproduction of native and non-native metabolites, Quantitative Biology 2014, 2(3): 100?109

10.Chao He, Xiaowo Wang*, Michael Q. Zhang*, Nucleosome eviction and multiple co-factor binding predict estrogen-receptor-alphaassociated long-range interactions, Nucleic Acid Research, 2014, 42(11):6935-44

11.Peng Xie, Yu Liu, Yan-da Li, Michael Zhang* and Xiaowo Wang*, MIROR: a method for cell-type specific microRNA occupancy rate prediction, Mol. BioSyst. 2014, 10 (6), 1377 - 1384

12.YingXue Li, XueNing Liu, Xiaowo Wang, XueGong Zhang, Sequence signatures of genes with accompanying antisense transcripts in Saccharomyces cerevisiae, Science China Life Sciences, 2014 Jan;57(1):52-58

13.Yong Chen, Yunfeng Ding, Yi Yang, Jinhai Yu, Guiing Liu, Xumin Wang, Shuyan Zhang, Dan Yu, Lai Song, Hangxiao Zhang, Congyan Zhang, Linhe Huo, Chaoxing Huo, Yang Wang, Yalan Du, Huina Zhang, PengZhang, Huimin Na, Shimeng Xu, Yaxin Zhu, Zhensheng Xie, Tong He, Yue Zhang, Guoliang Wang, Zhonghua Fan, Honglei Liu, Xiaowo Wang, Xuegong Zhang, Michael Q. Zhang, Yanda Li, Alexander Steinbuchel,Toyoshi Fujimoto, Simon Cichello, Jun Yu, Pingsheng Liu, Integrated omics study delineates the dynamics of lipid droplets in Rhodococcus opacus PD630, Nucleic Acids Research, 2014, 42(2):1052-64

14.Matthew H Larson, Luke A Gilbert, Xiaowo Wang, Wendell A Lim, Jonathan S Weissman & Lei S Qi, CRISPR interference (CRISPRi) for sequence-specific control of gene expression, Nature Protocols, 2013; 8, 2180?2196

15.Ruijuan Li, Weilong Guo, Jin Gu, Michael Q. Zhang, Xiaowo Wang*, Chromatin state and microRNA determine different gene expression dynamics responsive to TNF stimulation, Genomics, 2012 ;100(5):297-302

16.Ozlem Aksoy, Agustin Chicas, Tianying Zeng, Zhen Zhao, Mila McCurach, Xiaowo Wang, Scott Lowe, The atypical E2F family member E2F7 couples the p53 and Rb pathways during cellular senescence, Genes Dev.2012; 26(14):1546-57

17.Agustin Chicas#, Avnish Kapoor#, Xiaowo Wang#, Ozlem Aksoy, Adam G. Evertts, Michael Q. Zhang, Benjamin A. Garcia, Emily Bernstein*, Scott Lowe*, H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence, Proc Natl Acad Sci U S A. 2012 ;109(23):8971-6 (#equally contributed)

18.Ratnakumar K, Duarte LF, Leroy G, Hasson D, Smeets D, Vardabasso C, Bonisch C, Zeng T, Xiang B, Zhang DY, Li H, Wang X, Hake SB, Schermelleh L, Garcia BA, Bernstein E., ATRX-mediated chromatin association of histone variant macroH2A1 regulates α-globin expression, Genes Dev. 2012 Mar 1;26(5):433-8.

19.Miao He, Yu Liu, Xiaowo Wang, Michael Q. Zhang, Gregory Hannon, Z. Josh Huang, Cell-type based analysis of microRNA profiles in the mouse brain, Neuron, 2012, 73(1):35-48

20.Chien Y, Scuoppo C, Wang X, Fang X, Balgley B, Bolden JE, Premsrirut P, Luo W, Chicas A, Lee CS, Kogan SC, Lowe SW, Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity, Genes Dev.;25(20):2125-36, 2011

21.Wang LY, Wang P, Li MJ, Qin J, Wang X, Zhang MQ, Wang J. EpiRegNet: constructing epigenetic regulatory network from high throughput gene expression data for humans. Epigenetics. 2011 Dec 1;6(12):1505-12.

22.Likun Wang, Xiaowo Wang, Xi Wang, Xuegong Zhang, Yanchun Liang, Observations on novel splice junctions from RNA sequencing data, Biochemical and Biophysical Research Communications, 409(2):299-303, 2011

23.王曦, 汪小我, 王立坤, 冯智星, 张学工, 新一代高通量RNA测序数据的处理与分析, 生物化学与生物物理进展, 37(8):834-846, 2010

24.Agustin Chicas, Xiaowo Wang, Chaolin Zhang, Mila McCurrach, Zhen Zhao, Ozlem Mert, Ross A. Dickins, Masashi Narita, Michael Zhang and Scott W. Lowe, Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence, Cancer Cell, 17(4): 376-387, 2010

25.Tingting Li, Xueya Zhou, Xiaowo Wang, Dahai Zhu, Yong Zhang, Identification and characterization of human snoRNA core promoters, Genomics, 96(1):50-6, 2010

26.Likun Wang, Zhixing Feng, Xi Wang, Xiaowo Wang*, Xuegong Zhang*, DEGseq: an R package for identifying differentially expressed genes from RNA-seq data, Bioinformatics, 26(1):136-138 2010

27.Xiaowo Wang, Zhenyu Xuan, Xiaoyue Zhao, Yanda Li, Michael Q. Zhang, High-resolution human core-promoter prediction with CoreBoost_HM, Genome Research, 19(2):266-75, 2009

28.Xiaowo Wang , Jin Gu, Michael Q. Zhang and Yanda Li., Identification of phylogenetically conserved microRNA cis-regulatory elements across 12 Drosophila species, Bioinformatics, 15;24(2):165-71,2008

29.Tao Peng, Chenghai Xue, Jianning Bi, Tingting Li, Xiaowo Wang, Xuegong Zhang and Yanda Li, Functional importance of different patterns of correlation between adjacent cassette exons in human and mouse, BMC Genomics, 26;9:191, 2008

30.Xiaowo Wang , Xuegong Zhang, Yanda Li, Complicated evolutionary patterns of miRNAs in vertebrates, Sci China Ser C-Life Sci, 51(6):552-9 2008

31.汪小我,张学工,李衍达,脊椎动物中微小RNA进化模式研究, 中国科学C辑:生命科学,2008, 38(4):348-355

32.Jian Huang, Pei Hao, Yun-Li Zhang, Fu-Xing Deng, Qing Deng, Yi Hong, Xiaowo Wang, Yun Wang, Ting-Ting Li, Xue-Gong Zhang, Yi-Xue Li, Peng-Yuan Yang, Hong-Yang Wang and Ze-Guang Han. Discovering multiple transcripts of human hepatocytes using massively parallel signature sequencing (MPSS), BMC Genomics, 8:207,2007

33.Jin Gu, Tao He, Yunfei Pei, Fei Li, Xiaowo Wang, Jing Zhang, Xuegong Zhang and Yanda Li, Primary Transcripts and Expressions of Mammal Intergenic MicroRNAs Detected by Mapping ESTs to Their Flanking Sequences. Mamm Genome, 17(10):1033-1041, 2007

34.Xiaowo Wang, Jing Zhang, Fei Li , Jin Gu , Tao He , Xuegong Zhang and Yanda Li, MicroRNA identification based on sequence and structure alignment. Bioinformatics, 21 (18): 3610-4, 2005


主要课程:
博士识别基础(本科生,2017春-今)
计算分子生物学引论(研究生, 2009秋-今)
交叉项目综合训练A-合成生物学(本科生,2012年秋-今)
信息论基础(研究生,2010春-2016年春)