Yanda Li

Professor, Member of Chinese Academy of Science

Department of Automation

Tsinghua University,   Beijing 100084, China

Tel: +86(10) 6279 4295,   Fax: +86(10) 62794295

Email: daulyd@tsinghua.edu.cn

 Education

B.S. degree in automatic control, Tsinghua University, 1954.9-1959.7

  Working Experience

Associate professor and then professor, Department of Automation, Tsinghua University, 1983.3 -

Visiting scholar in MIT, 1978.10-1981.3.

TA, Department of Automation, Tsinghua University, 1970.9–1978.10.

TA, Department of Electrical Engineering, Tsinghua University, 1958.9–1970.9.

  Expertise and Research Interests

[1] Bioinformatics

Applying complex system information processing methods in molecular biology, such as research on the information structure of the genome sequences, gene regulatory network modeling and simulation, and the analysis of susceptibility genes for complex diseases etc.

[2] Intelligent information processing

Intelligent signal processing method and system research, such as artificial neural network and fuzzy system, expert system, theoretical model of evolutionary algorithm and the application in intelligent control of information network, information excavations, extraction and multimedia data compression and organizations under high-speed network environment, as well as the intelligent control of industrial production process and equipment.

[3] signal processing

Research on signal processing theory and application, such as signal reconstruction using partial data, wavelet analysis, fractal signal processing and seismic data processing.

  Academic/Social Activities and Memberships

Senior member of IEEE, 1983.1-

Convener of the subject consultative group (the Committee of Academic Degree) under the State Council, 1995.9-2005.9

Associate Editor-in-Chief, ACTA ELECTRONICA SINICA, 1997.7-2010.12

Editor-in-Chief, ACTA ELECTRONICA SINICA, 2011.1-

Editor-in-Chief, Frontiers of Electrical and Electronic Engineering in China, 2007-

Honorary director of intelligent automation specialized committee in Chinese Association of Automation, 1998.7-

Deputy director of Chinese Association of Automation, 1998.9-2007.9

Committee member of college council in Tsinghua University, 1999.9-

Chairman of the Education Committee of college electronic information and electrical science under The Ministry of Education, 2002.7-2007.9

   Grants and Contracts / Research Projects

ncRNAs (non-coding RNAs), Alternative Splicing, Complex Diseases (Current)

Research on drosophila miRNA regulatory mechanism, National Natural Science Foundation of China, 2008.1-2010.12

Analysis and information mining of non coding DNA, National Natural Science Foundation, 2006.1-2008.1

Research of some problems in bioinformatics using a complex system viewpoint, National Natural Science Foundation, 2003.1-2006.1

The earlier stage research on the systematic theory and technology of functional genomics, Ministry of Science and Technology, 2002.1-2004.1

   Honors and Awards

First Prize of National commission of science and technology progress prize, Ministry of Education of China, 1999

Information sciences award, Xinhongji Estate, 1999

Fourth Prize of Natural Science Award, Ministry of Science and Technology of China, 1997

Fourth Prize of Natural Science Award, Ministry of Science and Technology of China, 1993

First Prize of National commission of science and technology progress prize, Ministry of Education of China, 1991

Special Award of excellent teaching achievement prizes at the state education commission, Ministry of Education of China, 1989

Beijing science and technology progress prize, Beijing Municipal Science and Technology, 1986

Award for outstanding papers in Tsinghua University, Tsinghua University, 1984

   Academic Achievements

Selected Publications

[1] 李衍达. 信息世界漫谈. 清华大学出版社,2000

[2] 罗发龙, 李衍达. 神经网络信号处理. 电子工业出版社,1993

[3] 李衍达, 常同. 信号重构理论及应用. 清华大学出版社,1991

[4] Xin Yao, Han Hao, Yanda Li, Shao Li. Modularity-based credible prediction of disease genes and detection of disease subtypes on the phenotype-gene heterogeneous network. BMC System Biology,2011,5:79

[5] Jin Gu, Yang Chen, Shao Li, Yanda Li. Identification of responsive gene modules by network-based gene clustering and extending: application to inflammation and angiogenesis. BMC System Biology,2010,4:47

[6] Li Tang, Zhen Chen, Hao Yin, Jun Li, Yanda Li. CORS: A cooperative overlay routing service to enhance interactive multimedia communications. JOURNAL OF VISUAL COMMUNICATION AND IMAGE REPRESENTATION,2010,21(2):107-119

[7] X. Wang, Z. Xuan, X. Zhao, Y. Li, M. Q. Zhang. High-resolution human core-promoter prediction with CoreBoost_HM. GENOME RESEARCH, vol. 19, no. 2, pp. 266-275, Feb. 2009

[8] Wanwan Tang, Xuebing Wu, Rui Jiang, Yanda Li. Epistatic Module Detection for Case-Control Studies: A Bayesian Model with a Gibbs Sampling Strategy. PLoS Genet,2009,5(5):e1000464

[9] Pufeng Du, Shengjiao Cao and Yanda Li. SubChlo: Predicting protein subchloroplast locations with pseudo-amino acid composition and the evidence-theoretic K-nearest neighbor (ET-KNN) algorithm. Journal of Theoretical Biology,2009,261(2):330-335

[10] Pufeng Du, Liyan Jia and Yanda Li. CURE-Chloroplast: A chloroplast C-to-U RNA editing predictor for seed plants. BMC Bioinformatics,2009,10:135

[11] Jin Gu, Shao Li, Yang Chen, Yanda Li. Integrative computational identifications of the signaling pathway network related to TNF-alpha stimulus in vascular endothelial cells. International Joint Conference on Bioinformatics, Systems Biology and Intelligent Computing,2009,422-427

[12] Pufeng Du and Yanda Li. Computational analysis of RNA editing: seeking tiny discrepancies between transcriptome and genome. Frontiers of Electrical and Electronic Engineering in China,2009,4(3): 251-58

[13] Pufeng Du, Yang Chen and Yanda Li. Computational evidence of A-to-I RNA editing in nucleus transcriptome of Arabidopsis thaliana. Frontiers of Electrical and Electronic Engineering in China,2009,4(4):349-361

[14] Tao Peng, Pufeng Du and Yanda Li. PBEAM: A parallel implementation of BEAM for genome-wide inference of epistatic interactions. Bioinformation ,2009,3(8): 349-351

[15] Pufeng Du and Yanda Li. Prediction of C-to-U RNA editing sites in plant mitochondria using both biochemical and evolutionary information. Journal of Theoretical Biology,2008,253:579-586

[16] Tao Peng, Chenghai Xue, Jianning Bi, Xiaowo Wang, Xuegong Zhang, Yanda Li. Functional importance of different patterns of correlation between adjacent cassette exons in human and mouse. BMC Genomics,2008,9:191

[17] Jianning Bi, Tao Peng, Yanda Li. Evidence for association of multi-exon skipping events with tumors. Front Electr Electron Eng China,2008,3(3):260-266

[18] Xiaowo Wang, Jin Gu, Michael Zhang, Yanda Li. Identification of phylogenetically conserved microRNA cis-regulatory elements across 12 Drosophila species. Bioinformatics ,2008,24(2):165-171

[19] Xiaowo Wang , Xuegong Zhang, Yanda Li. Complicated evolutionary patterns of miRNAs in vertebrates. Sci China Ser C-Life Sci,2008,51(6):552-9

[20] 汪小我,张学工,李衍达. 脊椎动物中微小RNA进化模式研究. 中国科学C辑:生命科学,2008,38(4):348-355

[21] Zhang J, Ma T, Li YD, Li S. dbNEI2.0: building multilayer network for drug-NEI-disease. Bioinformatics,2008,24:2409-2411

[22] Jin Gu, Hu Fu, Xuegong Zhang, Yanda Li. Identifications of conserved 7-mers in 3-UTRs and microRNAs in Drosophila. BMC Bioinformatics,2007, 8:432

[23] Pufeng Du, Tao He, Yanda Li. Prediction of C-to-U RNA editing sites in higher plant mitochondria using only nucleotide sequence features. Biochem Biophys Res Commun,2007, 358(1):336-341

[24] Shao Li, Zhongqi Zhang, Lijiang Wu, Xuegong Zhang, Yanda Li, Wang Y.. Understanding ZHENG in Traditional Chinese Medicine in the context of neuro-endocrine-immune network. IEE Systems Biology,2007, 1(1):51-60

[25] Chaolin Zhang, Xuegong Zhang, Michael Q. Zhang, Yanda Li. Neighbor number, valley seeking and clustering. Pattern Recognition Letters,2007,28:173-180

[26] Tao He, Pufeng Du, Yanda Li. dbRES: a web-oriented database for annotated RNA Editing Sites. Nucleic Acids Res,2007, 35(Database issue):D141-4

[27] Huiyu Xia, Jianning Bi, Yanda Li. Identification of alternative 5/3 splice sites based on the mechanism of splice site competition. Nucleic Acids Res,2006, 34(21):6305-6313

[28] Jin Gu, Tao He, Yunfei Pei, Fei Li, Xiaowo Wang, Jing Zhang, Xuegong Zhang, Yanda Li. Primary Transcripts and Expressions of Mammal Intergenic MicroRNAs Detected by Mapping ESTs to Their Flanking Sequences. Mamm Genome,2006, 17(10):1033-1041

[29] Pufeng Du, Yanda Li. Prediction of protein submitochondria locations by hybridizing pseudo-amino acid composition with various physicochemical features of segmented sequence. BMC Bioiformatics,2006, 7:518

[30] Liyong Zhang, Fang Ding, Wenfeng Cao, Zhongmin Liu, Wei Liu, Zaicheng Yu, Yu Wu, Wendong Li, Yanda Li and Zhihua Liu. Stomatin-like Protein 2 Is Overexpressed in Cancer and Involved in Regulating Cell Growth and Cell Adhesion in Human Esophageal Squamous Cell Carcinoma. Clin Cancer Res, 2006, 12(5), 1639-1646

[31] Yandong Li, Zhongwei Ma, Wenkai Lu and Yanda Li. Automatic removal of the eye blink artifact from EEG using an ICA-based template matching approach. Physiological measurement, 2006, 27, 425

[32] Xiaowo Wang, Jing Zhang, Fei Li, Jin Gu, Tao He, Xuegong Zhang, Yanda Li. MicroRNA Identification Based On Sequence and Structure Alignment. Bioinformatics,2005, 21:3610-3614

[33] C. Xue, F. Li, T. He, G. Liu, Y. Li and X. Zhang. Classification of real and pseudo microRNA precursors using local structure-sequence features and support vector machine. BMC-Bioinformatics, vol.6, 2005.

[34] Fang Wen, Fei Li, Huiyu Xia, Xin Lu, Xuegong Zhang, Yanda Li. The impact of very short alternative splicing on protein structures and functions in the human genome. Trends in Genet ,2004, 20(5): 232-236

[35] Ying Huang, Yanda Li. Prediction of protein subcellular locations using fuzzy k-NN method. Bioinformatics,2004, 20: 21-28

[36] Ying Huang and Yanda Li. Prediction of protein subcellular locations using fuzzy k-NN method. . Bioinformatics,Vol.20, No.1, 2004, pp.21-28, DOI:10.1093/bioinformatics/btg366.

[37] Ying Huang, Jun Cai, Liang Ji, Yanda Li. Classifying G-protein coupled receptors with bagging classification tree. Computational biology and chemistry, 2004, 28 (4), 275-280

[38] Hongyuan Chen, Yanda Li. Performance model of IEEE 802.11 DCF with variable packet length. Communications Letters, IEEE, 2004, 8 (3), 186-188

[39] 许建华,张学工,李衍达. 支持向量机的新发展. 控制与决策,2004

[40] Qing Zhou and Yanda Li. Directed variation in evolution strategies. IEEE Trans. on Evolutionary Computation, Vol.7, No.4, August 2003

[41] Y. Sun, X. Fan, Y. Li. Identifying splicing sites in eukaryotic RNA: support machine approach. COMPUTERS IN BIOLOGY AND MEDICINE, vol.33, no.1, pp. 17-29, Jan. 2003

[42] 樊晓丹,孙应飞,李衍达. 一种基于RTW的实时控制系统快速开发方法. 2003, 43(7), 895-898

[43] 周晋, 路海明, 李衍达. 用Small-World 设计无组织 P2P系统的路由算法. 软件学报,2003,15(6), 915-923

[44] J Xu, LJ Zhang, H Lu, Y Li. The development and prospect of personalized TV program recommendation systems. Multimedia Software Engineering, 2002. Proceedings. Fourth International Symposium, 2002, 82-89

[45] 蔡登,卢增祥,李衍达. 信息协同过滤. 计算机科学, 2002, 29(6), 1-4

[46] 李梢(博士后),王永炎,季梁,李衍达(导师). 复杂系统意义下的中医药学及其案例研究.. 系统仿真学报,2002, 14(11) :1429-03

[47] Ji HK, Zhou Q, Wen F, Xia HY, Lu X, Li YD. . AsMamDB: an alternative splice database of mammals . Nucleic Acid Research,2001, 29: 260-263

[48] Jianhua Xu, Xuegong Zhang, Yanda Li. Kernel MSE algorithm: a unified framework for KFD, LS-SVM and KRR. Neural Networks, Proceedings. IJCNN '01. International Joint Conference, 2001, vol. 2, 1486-1491

[49] 阎辉,张学工,李衍达. 支持向量机与最小二乘法的关系研究. 清华大学学报(自然科学版), 2001, 41(9), 77-80

[50] 邹红星(研究生),戴琼海,李衍达. FMlet变换的子空间. 中国科学,2001,31,5

[51] 邹红星(研究生),戴琼海,李衍达,卢旭光. 不含交叉项干扰且具有WVD聚集性的时频分布之不存在性. 中国科学,2001,31,4,348-354

[52] 刘宇新(研究生),李衍达(导师). 基于重叠正交变换的自适应图像水印. 电子学报,2001,10,1368-1372

[53] 李衍达. 信息与生命. 化学通报,2001,10,601-607

[54] 李衍达. 以信息系统的观点了解基因组. 电子学报,2001, 29:1731-1734

[55] 邹红星,王殿军,戴琼海,李衍达. 延拓矩阵的奇异值分解. 科学通报,2000,45卷,14期,1560-1562

[56] 周杰,卢春雨,张长水,李衍达. 人脸自动识别方法综述. 电子学报,2000, 28(4): 102-106

[57] 邹红星,周小波,李衍达. 视频分析:回溯与前瞻. 电子学报,2000

[58] 阎辉,李鲲鹏,张学工,李衍达. 测井曲线的小波变换特性在自动分层中的应用. 地球物理学报, 2000, 43(4), 568-573

[59] 李衍达. 与信息科学的结合为生命科学的研究开辟新的前景. 中国科学基金,第13卷,第5期,1999,9,pp 307-308

[60] E. Gelenbe, Z. Mao, Y. Li. Function approximation with spiked random networks. IEEE Trans. On Neural Networks, vol. 10, no. 1, pp. 3-9, Jan. 1999

[61] Y. Tang, N. Zhang, Y. Li. Stable fuzzy adaptive control for a class of nonlinear systems. Fuzzy sets and systems (Elsevier), vol. 104, no. 2, pp. 279-288, 1999

[62] 周杰,卢春雨,张长水,李衍达. 基于方向对称变换的人脸定位方法. 电子学报,1999, 27(8), 12-15

[63] 卢增祥,李衍达. 交互支持向量机学习算法及其应用. 清华大学学报(自然科学版),1999, 39(7), 93-97

[64] H. Luo and Y. Li. The application of blind channel identification techniques to prestack seismic deconvolution. Proceedings of the IEEE,Vol.86,No.10,Oct,1998

[65] X Lu, Z Sun, H Chen, Y Li. Characterizing self-similarity in bacteria DNA sequences. Physical Review E, 1998, 58 (3), 3578

[66] C-B Xiao,X-D Zhang and Y-D Li. A new method for AR order determination of an ARMA process. IEEE Transon SP,Vol.44,No.11,Nov.1996

[67] X-D Zhang,Y。Song and Y-D Li. Adaptive identification of nonminimum phase ARMA models using higher order cumulants alone. IEEE Trans on SP,Vol.44,No.5,pp 1285-1288,May 1996

[68] 张良杰,李衍达. 模糊神经网络技术的新近发展. 信息与控制,1995, 24(1), 39-46

[69] Li Yanda. Information technological revolution and its impact on China. Computer Application on Petroleum Industry, Vol.2, 1994

[70] X-D Zhang and Y-D Li. Harmonic retrieval in mixed Gaussian and non-Gaussian ARMA noises。. IEEE Trans. on Signal Processing, Vol.42, No.12, Dec, 1994

[71] Luo Falong, Li Yanda. Real-time computation of the eigenvector corresponding to the smallest eigenvalue of a positive define matrix. IEEE Trans on Circuit and Systems,Vol.41,No.6,1994

[72] X. Zhang and Y. Li. The application of artificial neural networks in editing noisy seismic data. Chapter 7 in F. Aminzadeh & M. Jamshidi eds. “Soft Computing: Fuzzy Logic, Neural Networks, and Distributed Artificial Intelligence” Prentice-Hall, 1994

[73] Xuegong Zhang, Yanda Li. Self-organizing map as a new method for clustering and data analysis. Neural Networks, 1993. IJCNN '93-Nagoya. Proceedings of 1993 International Joint Conference. Vol. 3, 2448-2451

[74] Yen Ta Li,A.L.Kurkjian. Arrival time determination using iterative signal reconstruction from the phase of the cross spectrum。. IEEE Trans on ASSP, Vol ASSP-31, No.2, April, 1983

[75] Yanda Li. Improvement of maximum likelihood velocity spectrum estimation. ACTA GEOPHYSICA SINICA, Vol.26, No.2, March, 1983